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Which of the following is known to have a high potential for abuse?

Controlled substances

Controlled substances are known to have a high potential for abuse because they are drugs or other substances that are strictly regulated and have a high potential for dependence and addiction. These substances are often used recreationally due to their psychoactive effects and can cause serious harm if misused. Options B, C, and D do not have the same level of regulation and potential for abuse as controlled substances. Some over-the-counter medications may have addictive properties, but they are not considered controlled substances and are not as tightly regulated. Nutritional supplements and homeopathic remedies also do not have the same level of potential for dependence and addiction as controlled substances.

Over-the-counter medications

Nutritional supplements

Homeopathic remedies

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